Program

Dutch Translational Metabolism Conference
13-14th of June 2022
Hotel de Wageningsche Berg, Wageningen, The Netherlands

Themes of the conference:

• Cellular and molecular metabolism
• Systemic metabolism and inter-organ communication
• Lifestyle interventions
• Circadian Biology
• Drug discovery and therapeutics promoting energy metabolism
• Innovative methods for metabolic research

Day 1	13 June, 2022
9.30 – 10.30	Registration and coffee
10.30 – 10.45	Opening remarks
	Session 1
10.45 – 11.30	Keynote speaker: Prof. Kei Sakamoto (University of Copenhagen)  “Old and new insights into the role and therapeutic potential of the metabolic master AMPK”
11.30 – 11.50	Selected speaker: Judith de Jong (UMC Utrecht) “The effect of acetate on intestinal maturation in prevention of necrotizing enterocolitis”
11.50 – 12.10	Selected speaker: Xi Qi (Wageningen University) “Disruption of sarcoplasmic reticulum-mitochondrial contacts underlies contractile dysfunction in experimental and human atrial fibrillation: a key role of mitofusin 2”
12.10 – 12.30	Selected speaker: Jiske Tiersma (UMC Groningen) “Targeting glucose metabolism through inhibition of pyruvate dehydrogenase kinase to improve response to immune-checkpoint inhibition in melanoma”
12.30 – 13:30	Lunch
	Session 2
13.30 – 13.50	Selected speaker: Jayron Habibe (Amsterdam UMC) “FHL2 in mice and human pancreatic beta-cells negatively affects insulin secretion”
13.50– 14.10	Selected speaker: Cristy Verzijl (UMC Groningen) “A novel role for GalNAc-T2 dependent glycosylation in energy homeostasis”
14.10 – 14.30	Selected speaker: Sten van Beek (Maastricht UMC) “Treatment with the beta2-adrenergic agonist clenbuterol promotes insulin-stimulated skeletal muscle glucose uptake in healthy males”
14.30 – 15.15	Keynote speaker: Dr. Anja Zeigerer  (Helmholtz Centrum)  “Intracellular transport in systemic energy homeostasis and diabetes”
15.15 – 16.00	Break and check-in
16.00 – 17.00	Career trajectory masterclass with keynote speakers
17.00 – 17.45	Poster pitch presentations: Adam Sellers, Maastricht UMC Charlotte Andriessen, Maastricht UMC Irena Muffels, UMC Utrecht Gautam Kok, UMC Utrecht Moritz Eggelbusch, Amsterdam UMC Signe Mosegaard Nielsen, Amsterdam UMC Milena Schönke, Leiden UMC Maria Colman, UMC Utrecht Jeroen van der Velde, Leiden UMC Martijn Rutten, UMC Groningen
17.45 – 21.00	Dinner and poster session
21.00 –	Evening program
Day 2	14 June, 2022
7.30 – 8.15	Boot camp
8.30 – 9.30	Breakfast
	Session 3
9.30 – 9.50	Selected speaker: Anouk Gijbels (Wageningen U) “Precision nutrition by targeting diets according to tissue-specific insulin resistance phenotypes improves markers of cardiometabolic disease risk: the PERSON study”
9.50 – 10.10	Selected speaker: Alex Schuurman (Amsterdam UMC) “The shifting lipidomic landscape of monocytes and neutrophils during pneumonia”
10.15 – 11.00	Keynote speaker: Dr. Giles Yeo  (University of Cambridge) “Is obesity a choice?”
11.00 – 11.30	Coffee break
	Session 4
11.30 – 11.50	Selected speaker: Amee Buziau (Maastricht UMC) “A common variant in the ketohexokinase gene is associated with fructosuria and cardiometabolic outcomes”
11.50 – 12.10	Selected speaker: Elise Ferreira (Amsterdam UMC) “Diagnosing, Discarding or De-VUSsing: a practical guide to (un)targeted metabolomics as variant-transcending functional tests”
12.15 – 13.00	Keynote speaker: Prof. Anu Suomalainen Wartiovaara (University of Helsinki) “Metabolic modifier therapies and cell-specific stress responses: complex physiology of mitochondrial disease”
13.00 – 14.00	Lunch
	Session 5
14.00 – 14.20	Selected speaker: Froukje Vanweert (Maastricht UMC) “Lowering branched-chain amino acid levels in patients type 2 diabetes by sodium-phenylbutyrate improves insulin sensitivity”
14.20 – 14.40	Selected speaker: Rodrigo Mancilla (Maastricht UMC) “High intensity interval training improves whole-body insulin sensitivity and skeletal muscle oxidative capacity and favorably affects hepatic fat storage”
14.45 – 15.30	Keynote speaker: Prof. Lora Heisler (University of Aberdeen) “Targeting the brain to improve obesity and type 2 diabetes”
15.30 – 16.00	Final remarks, Conference evaluation, and Prizes