Please note, the following program was planned for 10-11 March 2020. We aim to reschedule the meeting for early fall, and hopefully maintain as much of the same program as possible.
| Day 1 | 10 March, 2020 |
| 9.30 – 10.30 | Registration and coffee |
| 10.30 – 10.45 | Opening remarks |
| Session 1: Drug intervention studies promoting energy metabolism | |
| 10.45 – 11.05 | Selected speaker: Dicky Struik (UMCG) – The translational potential of fibroblast growth factor 1 in the treatment of chronic metabolic diseases |
| 11.05 – 11.25 | Selected speaker: Ellen de Heer (UMCG) – Downregulation of glycogen synthase 1 (GYS1) decreases breast cancer cell proliferation and enhances sensitivity to mitochondrial inhibition |
| 11.25 – 11.45 | Selected speaker: Esther Zaal (UU) – Rewiring of energy metabolism drives resistance to the proteasome inhibitor bortezomib |
| 11.45 – 12.30 | Keynote: Prof. Dr. Stephan Herzig (Helmholtz Diabetes Center) – Tissue communication in metabolic control |
| 12.30 – 13.30 | Lunch |
| Session 2: Intracellular and molecular metabolism | |
| 13.30 – 13.50 | Selected speaker: Stijn Meijnikman (AUMC) – Hyperinsulinemia, a key player in visceral adipose tissue and hepatic cellular senescence |
| 13.50 – 14.10 | Selected speaker: Jeffrey Kroon (AUMC) – Atherogenic lipoprotein(a) increases vascular glycolysis, thereby facilitating inflammation and leukocyte extravasation |
| 14.10 – 14.30 | Selected speaker: Edgar Nollet (AUMC) – Mitochondrial dysfunction is common in clinical and experimental settings of hypertrophic cardiomyopathy |
| 14.30 – 15.15 | Keynote: Prof. Dr. Johan Auwerx (École Polytechnique Fédérale de Lausanne) – Systems genetics approaches to explore mitochondria and aging |
| 15.15 – 16.00 | Coffee break |
| 16.00 – 17.00 | Honorary lecture: Prof. Dr. Ronald Wanders (Amsterdam UMC) Human metabolism requires the crosstalk between different subcellular organelles: Lessons learned from genetic metabolic diseases |
| 17.00 – 17.45 | Poster pitch presentations: Jeroen Baardman (AUMC) Anne Gemmink (MUMC) Andrea Kodde (Danone) Jiayi Pei (UMCU) Katrin Rabold (RUMC) Martijn Rutten (UMCG) Milena Schönke (LUMC) Pomme Simons (MUMC) Katy van Galen (AUMC) Taolin Yuan (WUR) |
| 17.45 – 21.00 | Poster session with dinner and drinks |
| 21.00 – | Evening program |
| Day 2 | 11 March, 2020 |
| 7.30 – 8.15 | Boot camp |
| 8.30 – 9.30 | Breakfast |
| Session 3: Systemic metabolism and inter-organ communication | |
| 9.30 – 9.50 | Selected speaker: Xinwei Chang (MUMC) – The effect of chyme reinfusion on the bile salt/fibroblast growth factor 19 signaling axis in intestinal failure patients with a temporary jejunal double enterostomy |
| 9.50 – 10.10 | Selected speaker: Joanne Hoogerland (Institut Pasteur de Lille/UMCG) – Hypoglycemia aggravates dyslipidemia in GSD Ia via enhanced adipocyte lipolysis and impaired VLDL catabolism |
| 10.15 – 11.00 | Keynote: Prof. Dr. Saskia van Mil (UMC Utrecht) – FXR isoforms control distinct hepatic metabolic functions via selective DNA binding. |
| 11.00 – 11.30 | Coffee tasting |
| Session 4: Lifestyle interventions and circadian biology | |
| 11.30 – 11.50 | Selected speaker: Jeroen van der Velde (LUMC) – Liver fat, visceral fat and total body fat as mediators in the associations of physical activity and sedentary time with insulin resistance |
| 11.50 – 12.10 | Selected speaker: Jan‐Frieder Harmsen (MUMC) – Human skeletal muscle exhibits a day‐night rhythm in lipid droplets and in the muscle lipidome |
| 12.15 – 13.00 | Keynote: Dr. Pam Taub (University of California San Diego) – Impact of time restricted eating on cardiometabolic disease |
| 13.00 – 14.00 | Lunch |
| Session 5: Innovative methods for metabolic research | |
| 14.00 – 14.20 | Selected speaker: Andrea Cabbia (TU/e) – Characterization of individual responses to endurance training in older adults’ skeletal muscle metabolism using genome‐scale metabolic models |
| 14.20 – 14.50 | Selected speaker: Tineke van de Weijer (MUMC) – PCr/ATP ratio’s measured with 31P‐MRS do not reflect atrial cardiac mitochondrial function |
| 14.55 – 15.30 | Keynote: Prof. Dr. Marc Hellerstein (University of California Berkeley) – Measuring molecular flux rates in humans through pathways that drive disease: Recent advances and applications in clinical medicine and drug development |
| 15.30 – 16.00 | Final remarks, Conference evaluation, and Prizes |